(SCROLL DOWN THROUGH ALL GENE SPECIFIC DATA)
Search our RNA-seq data here (E0.5 through E7.5)
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We have characterized a large number of mutant alleles generated by the Knock-out Mouse Consortium (KOMP2) that have lethal phenotypes occurring before E9.5. Thus far we have analyzed more than 100 distinct knockout lines produced by the Knock Out Mouse Project. Here we provide data summarizing each early lethal mutant phenotype. More information about the international effort to understand the function of all protein coding genes available on the International Mouse Phenotyping Consortium website. We find approximately half of homozygous knockout embryos can be recovered at E7.5 but arrest prior to gastrulation. The other half cannot be found at E7.5 but are recovered during preimplantation stages with ~25% arresting/dying prior to blastocyst formation while the other ~25% form normal blastocysts but fail to implant. To our knowledge this is the first systematic study of early lethal knockouts conducted using similar mutation strategies on the same genetic background (C57Bl/6JN). Summary data for each phenotype available below. Full data sets and information available by contacting Dr. Jesse Mager (jmager@umass.edu).
4933427D14Rik
Click HERE for high resolution 4933427D14Rik data slide
OMIM data for 4933427D14Rik
ExAC data for 4933427D14Rik
Aasdhppt
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Aatf

Actr8
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OMIM data for Actr8
Alg14
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Ap2s1
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Atp2b1
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Atp5d

B4gat1
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ExAC data for B4gat1
BC052040
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OMIM data for BC052040
ExAC data for BC052040
Bcs1l
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Borcs6
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Exac data for Borcs6
Casc3
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Ccdc59
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OMIM data for Ccdc59
Cenpo
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Clpx
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Dbr1
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Dctn6
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Ddx21

Ddx46

Ddx59
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OMIM data for Ddx59
Dhx37

Dnaaf2
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Dnajc13

Dolk
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Eif5b

Eipr1

Click HERE for Eipr1 high resolution data slide
ExAC data for Eipr1
Elof1
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Click HERE for our recent paper “The elongation factor Elof1 is required for mammalian gastrulation.
OMIM data for Elof1
Exoc2
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Fastkd5
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Glrx3
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Haus4

Hlcs
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Ipo11
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Ipo7

Isca1
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Lin52

Ltv1

Mars2
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Mbip

Mcrs1
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Med20
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Cui et al “Med20 is essential for early embryogenesis and regulates Nanog expression.” Reproduction 2018
Mepce
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Mrm3
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Mrpl22
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Mrpl3
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Mrpl44
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Mrps18c
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Mrps22
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Mrps25
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Mtpap
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Nars

Nars2
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Ncapd3

Ndc80

Ndufa9
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Ndufs8
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Nsl1

Nup155

Nup205

Orc2

Orc6
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Pmpcb
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Pold2
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Polr1a
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Polr1d
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Ppp1r35
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OMIM data for Ppp1r35
Prim1
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Prpf40a
In Process
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Prpf4b
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Rab11a
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Ranbp2
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Rbbp4
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Riok1
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Rpain
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Sars
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Scfd1

Sdhaf2
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Ska2
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Snapc2
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Sptssa
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Strn3
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Thoc7

Timm22
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Tmx2
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Tomm20

Tpk1
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Trit1
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Ttk

Tubgcp4
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Ube2m
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Utp4
In Process
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Washc4
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ExAC data for Washc4
Wdr73

Ylpm1
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OMIM data for Ylpm1
Zc3h4
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OMIM data for Zc3h4
Zfp407
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OMIM data for Zfp407
ExAC data for Zfp407
Zwint
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