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Search our RNA-seq data here (E0.5 through E7.5)

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We have characterized a large number of mutant alleles generated by the Knock-out Mouse Consortium (KOMP2) that have lethal phenotypes occurring before E9.5. Thus far we have analyzed more than 100 distinct  knockout lines produced by the Knock Out Mouse Project. Here we provide data summarizing each early lethal mutant phenotype. More information about the international effort to understand the function of all protein coding genes available on the International Mouse Phenotyping Consortium website.  We find approximately half of homozygous knockout embryos can be recovered at E7.5 but arrest prior to gastrulation.  The other half cannot be found at E7.5 but are recovered during preimplantation stages with ~25% arresting/dying prior to blastocyst formation while the other ~25% form normal blastocysts but fail to implant. To our knowledge this is the first systematic study of early lethal knockouts conducted using similar mutation strategies on the same genetic background (C57Bl/6JN).  Summary data for each phenotype available below. Full data sets and information available by contacting Dr. Jesse Mager (jmager@umass.edu).

 

4933427D14Rik

Click HERE for high resolution 4933427D14Rik data slide

IMPC data for 4933427D14Rik

MGI data for 4933427D14Rik

OMIM data for 4933427D14Rik

ExAC data for 4933427D14Rik

Aasdhppt

Click HERE for high resolution Aasdhppt data slide

IMPC data for Aasdhppt

MGI data for Aasdhppt

OMIM data for Aasdhppt

ExAC data for Aasdhppt

Aatf

IMPC data for Aatf

MGI data for Aatf

OMIM data for Aatf

Actr8

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IMPC data for Actr8

MGI data for Actr8

OMIM data for Actr8

ExAC data for Actr8

Alg14

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IMPC data for Alg14

MGI data for Alg14

OMIM data for Alg14

ExAC data for Alg14

Ap2s1

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IMPC data for Ap2s1

MGI data for Ap2s1

OMIM data for Ap2s1

ExAC data for Ap2s1

Atp2b1

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IMPC data for Atp2b1

MGI data for Atp2b1

OMIM data for Atp2b1

ExAC data for Atp2b1

Atp5d

IMPC data for Atp5d

MGI data for Atp5d

Atp6v1f

IMPC data for Atp6v1f

MGI data for Atp6v1f

OMIM data for Atp6v1f

B4gat1

Click HERE for high resolution B4gat1 data slide

IMPC data for B4gat1

MGI data for B4gat1

OMIM data for B4gat1

ExAC data for B4gat1

BC052040

Click HERE for high resolution BC0502040 data slide

IMPC data for BC052040

MGI data for BC052040

OMIM data for BC052040

ExAC data for BC052040

Bcs1l

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IMPC data for Bcs1l

MGI data for Bcs1l

OMIM data for Bcs1l

ExAc data for Bcs1l

Borcs6

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IMPC data for Borcs6

MGI data for Borcs6

OMIM data for Borcs6

Exac data for Borcs6

Casc3

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IMPC data for Casc3

MGI data for Casc3

OMIM data for Casc3

ExAC data for Casc3

Ccdc59

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IMPC data for Ccdc59

MGI data for Ccdc59

OMIM data for Ccdc59

ExAC data for Ccdc59

Cdc37

IMPC data for Cdc37

MGI data for Cdc37

OMIM data for Cdc37

Cenpo

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IMPC data for Cenpo

MGI data for Cenpo

OMIM data for Cenpo

ExAC data for Cenpo

Cherp

IMPC data for Cherp

MGI data for Cherp

OMIM data for Cherp

Clpx

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IMPC data for Clpx

MGI data for Clpx

OMIM data for Clpx

ExAC data for Clpx

Dbr1

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IMPC data for Dbr1

MGI data for Dbr1

OMIM data for Dbr1

ExAC data for Dbr1

Dctn6

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IMPC data for Dctn6

MGI data for Dctn6

OMIM data for Dctn6

ExAC data for Dctn6

Ddx21

IMPC data for Ddx21

MGI data for Ddx21

OMIM data for Ddx21

Ddx46

IMPC data for Ddx46

MGI data for Ddx46

OMIM data for Ddx46

Ddx59

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IMPC data for Ddx59

MGI data for Ddx59

OMIM data for Ddx59

ExAC data for Ddx59

Dhx37

IMPC data for Dhx37

MGI data for Dhx37

OMIM data for Dhx37

Dnaaf2

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IMPC data for Dnaaf2

MGI data for Dnaaf2

OMIM data for Dnaaf2

ExAC data for Dnaaf2

Dnajc13

IMPC data for Dnajc13

MGI data for Dnajc13

OMIM data for Dnajc13

Dolk

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IMPC data for Dolk

MGI data for Dolk

OMIM data for Dolk

ExAC data for Dolk

Eif5b

IMPC data for Eif5b

MGI data for Eif5b

OMIM data for Eif5b

Eipr1

Click HERE for Eipr1 high resolution data slide

IMPC data for Eipr1

MGI data for Eipr1

OMIM data for Eipr1

ExAC data for Eipr1

Efl1

IMPC data for Efl1

MGI data for Efl1

OMIM data for Efl1

Elof1

Click HERE for high resolution Elof1 data slide

Click HERE for our recent paper “The elongation factor Elof1 is required for mammalian gastrulation.

IMPC data for Elof1

MGI data for Elof1

OMIM data for Elof1

ExAC data for Elof1

Exoc2

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IMPC data for Exoc2

MGI data for Exoc2

OMIM data for Exoc2

ExAC data for Exoc2

Exosc2

IMPC data for Exosc2

MGI data for Exosc2

OMIM data for Exosc2

Fastkd5

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IMPC data for Fastkd5

MGI data for Fastkd5

OMIM data for Fastkd5

ExAC data for Fastkd5

Gemin6

IMPC data for Gemin6

MGI data for Gemin6

OMIM data for Gemin6

Glrx3

Click HERE for high resolution Glrx3 data slide

IMPC data for Glrx3

MGI data for Glrx3

OMIM data for Glrx3

ExAC data for Glrx3

Gtpbp4

IMPC data for Gtpbp4

MGI data for Gtpbp4

OMIM data for Gtpbp4

Haus4

IMPC data for Haus4

MGI data for Haus4

OMIM data for Haus4

Hlcs

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IMPC data for Hlcs

MGI data for Hlcs

OMIM data for Hlcs

ExAC data for Hlcs

Ipo11

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IMPC data for Ipo11

MGI data for Ipo11

OMIM data for Ipo11

ExAC data for Ipo11

Ipo7

IMPC data for Ipo7

MGI data for Ipo7

OMIM data for Ipo7

Isca1

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IMPC data for Isca1

MGI data for Isca1

OMIM data for Isca1

ExAC data for Isca1

Lin52

IMPC data for Lin52

MGI data for Lin52

Ltv1

IMPC data for Ltv1

MGI data for Ltv1

Mars2

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IMPC data for Mars2

MGI data for Mars2

OMIM data for Mars2

ExAC data for Mars2

Mbip

IMPC data for Mbip

MGI data for Mbip

OMIM data for Mbip

Mcrs1

Click HERE for high resolution Mcrs1 data slide

IMPC data for Mcrs1

MGI data for Mcrs1

OMIM data for Mcrs1

ExAC data for Mcrs1

Med20

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Cui et al “Med20 is essential for early embryogenesis and regulates Nanog expression.” Reproduction 2018

IMPC data for Med20

MGI data for Med20

OMIM data for Med20

ExAC data for Med20

Mepce

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IMPC data for Mepce

MGI data for Mepce

OMIM data for Mepce

ExAC data for Mepce

Mrm3

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IMPC data for Mrm3

MGI data for Mrm3

OMIM data for Mrm3

ExAC data for Mrm3

Mrpl22

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IMPC data for Mrpl22

MGI data for Mrpl22

OMIM data for Mrpl22

ExAC data for Mrpl22

Mrpl3

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IMPC data for Mrpl3

MGI data for Mrpl3

OMIM data for Mrpl3

ExAC data for Mrpl3

Mrpl41

IMPC data for Mrpl41

MGI data for Mrpl41

OMIM data for Mrpl41

Mrpl44

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IMPC data for Mrpl44

MGI data for Mrpl44

OMIM data for Mrpl44

ExAC data for Mrpl44

Mrps18c

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IMPC data for Mrps18c

MGI data for Mrps18c

OMIM data for Mrps18c

ExAC data for Mrps18c

Mrps22

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IMPC data for Mrps22

MGI data for Mrps22

OMIM data for Mrps22

ExAC data for Mrps22

Mrps25

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IMPC data for Mrps25

MGI data for Mrps25

OMIM data for Mrps25

ExAC data for Mrps25

Mtpap

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IMPC data for Mtpap

MGI data for Mtpap

OMIM data for Mtpap

ExAC data for Mtpap

Nars

IMPC data for Nars

MGI data for Nars

OMIM data for Nars

Nars2

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IMPC data for Nars2

MGI data for Nars2

OMIM data for Nars2

ExAC data for Nars2

Ncapd3

IMPC data for Ncapd3

MGI data for Ncapd3

OMIM data for Ncapd3

Ndc80

IMPC data for Ndc80

MGI data for Ndc80

OMIM data for Ndc80

Ndufa9

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IMPC data for Ndufa9

MGI data for Ndufa9

OMIM data for Ndufa9

ExAC data for Ndufa9

Ndufs8

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IMPC data for Ndufs8

MGI data for Ndufs8

OMIM data for Ndufs8

ExAC data for Ndufs8

Nsl1

IMPC data for Nsl1

MGI data for Nsl1

OMIM data for Nsl1

Nup155

IMPC data for Nup155

MGI data for Nup155

OMIM data for Nup155

ExAC data for Nup155

Nup205

IMPC data for Nup205

MGI data for Nup205

OMIM data for Nup205

Orc2

IMPC data for Orc2

MGI data for Orc2

OMIM data for Orc2

Orc6

Click HERE for high resolution Orc6 data slide

IMPC data for Orc6

MGI data for Orc6

OMIM data for Orc6

ExAC data for Orc6

Osbp

IMPC data for Osbp

MGI data for Osbp

OMIM data for Osbp

Pmpcb

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IMPC data for Pmpcb

MGI data for Pmpcb

OMIM data for Pmpcb

ExAC data for Pmpcb

Pold2

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IMPC data for Pold2

MGI data for Pold2

OMIM data for Pold2

ExAC data for Pold2

Polr1a

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IMPC data for Polr1a

MGI data for Polr1a

OMIM data for Polr1a

ExAC data for Polr1a

Polr1d

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IMPC data for Polr1d

MGI data for Polr1d

OMIM data for Polr1d

ExAC data for Polr1d

Polr2d

IMPC data for Polr2b

MGI data for Polr2b

OMIM data for Polr2b

Pop5

IMPC data for Pop5

MGI data for Pop5

OMIM data for Pop5

Ppp1r35

Click HERE for Ppp1r35 high resolution data slide

IMPC data for Ppp1r35

MGI data for Ppp1r35

OMIM data for Ppp1r35

ExAC data for Ppp1r35

Prim1

Click HERE for high resolution Prim1 data slide

IMPC data for Prim1

MGI data for Prim1

OMIM data for Prim1

ExAC data for Prim1

Prpf40a

In Process

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IMPC data for Prpf40a

MGI data for Prpf40a

OMIM data for Prpf40a

ExAC data for Prpf40a

Prpf4b

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IMPC data for Prpf4b

MGI data for Prpf4b

OMIM data for Prpf4b

ExAC data for Prpf4b

Rab11a

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IMPC data for Rab11a

MGI data for Rab11a

OMIM data for Rab11a

ExAC data for Rab11a

Ranbp2

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IMPC data for Ranbp2

MGI data for Ranbp2

OMIM data for Ranbp2

ExAC data for Ranbp2

Rbbp4

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IMPC data for Rbbp4

MGI data for Rbbp4

OMIM data for Rbbp4

ExAC data for Rbbp4

Riok1

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IMPC data for Riok1

MGI data for Riok1

OMIM data for Riok1

ExAC data for Riok1

Rpain

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IMPC data for Rpain

MGI data for Rpain

OMIM data for Rpain

ExAC data for Rpain

Sars

Click HERE for high resolution Sars data slide

IMPC data for Sars

MGI data for Sars

OMIM data for Sars

ExAC data for Sars

Scfd1

IMPC data for Scfd1

MGI data for Scfd1

OMIM data for Scfd1

Sdhaf2

Click HERE for high resolution Sdhaf2 data slide

IMPC data for Sdhaf2

MGI data for Sdhaf2

OMIM data for Sdhaf2

ExAC data for Sdhaf2

Sepsecs

IMPC data for Sepsecs

MGI data for Sepsecs

OMIM data for Sepsecs

Ska2

Click HERE for high resolution Ska2 data slide

IMPC data for Ska2

MGI data for Ska2

OMIM data for Ska2

ExAC data for Ska2

Smarce1

IMPC data for Smarce1

MGI data for Smarce1

OMIM data for Smarce1

Snapc2

Click HERE for high resolution Snapc2 data slide

IMPC data for Snapc2

MGI data for Snapc2

OMIM data for Snapc2

ExAC data for Snapc2

Sptssa

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IMPC data for Sptssa

MGI data for Sptssa

OMIM data for Sptssa

ExAC data for Sptssa

 Strn3

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IMPC data for Strn3

MGI data for Strn3

OMIM data for Strn3

ExAC data for Strn3 

Tbcc

IMPC data for Tbcc

MGI data for Tbcc

OMIM data for Tbcc

Tbcd

IMPC data for Tbcd

MGI data for Tbcd

OMIM data for Tbcd

Thoc3

IMPC data for Thoc3

MGI data for Thoc3

OMIM data for Thoc3

Thoc7

IMPC data for Thoc7

MGI data for Thoc7

OMIM data for Thoc7

Timm22

Click  HERE for high resolution Timm22 data slide

IMPC data for Timm22

MGI data for Timm22

OMIM data for Timm22

ExAC data for Timm22

Tmx2

Click HERE for high resolution Tmx2 data slide

IMPC data for Tmx2

MGI data for Tmx2

OMIM data for Tmx2

ExAC data for Tmx2 

Tomm20

IMPC data for Tomm20

MGI data for Tomm20

OMIM data for Tomm20

ExAC data for Tomm20

Tpk1

Click HERE for high resolution Tpk1 data slide

IMPC data for Tpk1

MGI data for Tpk1

OMIM data for Tpk1

ExAC data for Tpk1

Trit1

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IMPC data for Trit1

MGI data for Trit1

OMIM data for Trit1

ExAC data for Trit1

IMPC data for Tsen54

MGI data for Tsen45

OMIM data for Tsen54

Ttk

IMPC data for Ttk

MGI data for Ttk

OMIM data for Ttk

Tubgcp4

Click HERE for high resolution Tubgcp4 data slide

IMPC data for Tubgcp4

MGI data for Tubgcp4

OMIM data for Tubgcp4

ExAC data for Tubgcp4

U2af2

IMPC data for U2af2

MGI data for U2af2

OMIM data for U2af2

Ube2m

Click HERE for high resolution Ube2m data slide

IMPC data for Ube2m

MGI data for Ube2m

OMIM data for Ube2m

ExAC data for Ube2m

Uqcr10

IMPC data for Uqcr10

MGI data for Uqcr10

OMIM data for Uqcr10

Utp4

In Process

Click HERE for high resolution Utp4 data slide

IMPC data for Utp4

MGI data for Utp4

OMIM data for Utp4

ExAC data for Utp4

Washc4

Click HERE for high resolution Wasch4 data slide

IMPC data for Washc4

MGI data for Washc4

OMIM data for Washc4

ExAC data for Washc4

Wdr73

IMPC data for Wdr73

MGI data for Wdr73

OMIM data for Wdr73

Ykt6

IMPC data for Ykt6

MGI data for Ykt6

OMIM data for Ykt6

Ylpm1

Click HERE for high resolution Ylpm1 data slide

IMPC data for Ylpm1

MGI data for Ylpm1

OMIM data for Ylpm1

ExAC data for Ylpm1

Zc3h4

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IMPC data for Zc3h4

MGI data for Zc3h4

OMIM data for Zc3h4

ExAC data for Zc3h4

Zfp407

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IMPC data for Zfp407

MGI data for Zfp407

OMIM data for Zfp407

ExAC data for Zfp407

 Zwint

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IMPC data for Zwint

MGI data for Zwint

OMIM data for Zwint

ExAC data for Zwint

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