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Search our RNA-seq data here (E0.5 through E7.5)
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We have characterized a large number of mutant alleles generated by the Knock-out Mouse Consortium (KOMP2) that have lethal phenotypes occurring before E9.5. Thus far we have analyzed more than 100 distinct knockout lines produced by the Knock Out Mouse Project. Here we provide data summarizing each early lethal mutant phenotype. More information about the international effort to understand the function of all protein coding genes available on the International Mouse Phenotyping Consortium website. We find approximately half of homozygous knockout embryos can be recovered at E7.5 but arrest prior to gastrulation. The other half cannot be found at E7.5 but are recovered during preimplantation stages with ~25% arresting/dying prior to blastocyst formation while the other ~25% form normal blastocysts but fail to implant. To our knowledge this is the first systematic study of early lethal knockouts conducted using similar mutation strategies on the same genetic background (C57Bl/6JN). Summary data for each phenotype available below. Full data sets and information available by contacting Dr. Jesse Mager (jmager@umass.edu).
4933427D14Rik
OMIM data for 4933427D14Rik
ExAC data for 4933427D14Rik
Aasdhppt
Aatf
Actr8
OMIM data for Actr8
Alg14
Ap2s1
Atp2b1
Atp5d
Atp6v1f
B4gat1
ExAC data for B4gat1
BC052040
OMIM data for BC052040
ExAC data for BC052040
Bcs1l
Borcs6
Exac data for Borcs6
Casc3
Ccdc59
OMIM data for Ccdc59
Cdc37
Cenpo
Cherp
Clpx
Dbr1
Dctn6
Ddx21
Ddx46
Ddx59
OMIM data for Ddx59
Dhx37
Dnaaf2
Dnajc13
Dolk
Ebna1bp2
Eif5b
Eipr1
ExAC data for Eipr1
Efl1
Elof1
Click HERE for our recent paper “The elongation factor Elof1 is required for mammalian gastrulation.
OMIM data for Elof1
Exoc2
Exosc2
Fastkd5
Gemin6
Glrx3
Gtpbp4
Haus4
Hlcs
Ipo11
Ipo7
Isca1
Lin52
Ltv1
Mars2
Mbip
Mcrs1
Med20
Cui et al “Med20 is essential for early embryogenesis and regulates Nanog expression.” Reproduction 2018
Mepce
Mrm3
Mrpl22
Mrpl3
Mrpl41
Mrpl44
Mrps18c
Mrps22
Mrps25
Mtpap
Nars
Nars2
Ncapd3
Ndc80
Ndufa9
Ndufs8
Nsl1
Nup155
Nup205
Orc2
Orc6
Osbp
Pmpcb
Pold2
Polr1a
Polr1d
Polr2d
Pop5
Ppp1r35
OMIM data for Ppp1r35
Prim1
Prpf40a
In Process
Click HERE for high resolution Prpf40a data slide
Prpf4b
Rab11a
Ranbp2
Rbbp4
Riok1
Rpain
Sars
Scfd1
Sdhaf2
Sepsecs
Ska2
Smarce1
Snapc2
Sptssa
Strn3
Tbcc
Tbcd
Thoc3
Thoc7
Timm22
Tmx2
Tomm20
Tpk1
Trit1
Ttk
Tubgcp4
U2af2
Ube2m
Uqcr10
Utp4
In Process
Click HERE for high resolution Utp4 data slide
Washc4
ExAC data for Washc4
Wdr73
Ykt6
Ylpm1
OMIM data for Ylpm1
Zc3h4
OMIM data for Zc3h4
Zfp407
OMIM data for Zfp407
ExAC data for Zfp407