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NSB Seminar – Roger Colbran
September 25, 2019 @ 4:00 pm - 5:00 pm
September 25, 2019, 4:00 p.m.
Morrill 2, Room 222
Roger Colbran
Professor, Vanderbilt School of Medicine
Colbran Lab
Molecular Physiology and Biophysics
“Synaptic CaMKII signaling: new ‘tricks’ for an old kinase”
Calcium-calmodulin-dependent protein kinase II (CaMKII) is an abundant neuronal protein first characterized about 40 years ago. We now know that its structure is ideally suited to respond to dynamic changes in synaptic calcium concentrations and serve as a “memory molecule”, with critical roles in long-term potentiation and spatial learning. Recent work has uncovered much more diverse synaptic roles for CaMKII. I will discuss these novel synaptic roles of CaMKII, as well as studies linking mutations in CaMKII to neuropsychiatric disorders, including autism.
