The University of Massachusetts Amherst
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Our research focuses on prevention of colonic inflammation (inflammatory bowel disease) and colon cancer. We address two major issues: (1) identification and characterization of novel environmental and dietary factors which are risk factors of these two diseases. We study how environmental and dietary compounds modulate gut microbiome and innate immunity signaling to exaggerate inflammatory responses and tumorigenesis; and (2) discovery of novel therapeutic targets and biomarkers of these two diseases. We use LC-MS/MS-based lipidomics, transgenic animal models to study the roles of eicosanoid signaling pathways in colonic inflammation and colon cancer.