A human being is like a delicate machine. From engineers’ perspective, we are curious about how this machine is built and how to fix it when it goes awry. Specifically, we are interested in how mechanical information, encoded in nano-scale molecules, guides micro-scale cells to assemble into mili-scale functional tissues and organs. We also develop tools that interact with biomolecules, cells and tissues for a range of applications from diagnostics of diseases to regenerative medicine.
We are interested in the mechanical regulation of stem cell fate, i.e., how stem cells respond to the rigidity of extracellular matrix, external forces, nanotopographical cues, geometric constraints, etc. We develop micro/nanoscale micromechanical tools to control these mechanical cues and combine with molecular and cell biology approaches to understand the mechanobiology.
Pluripotent stem cells are powerful tools to understand the development processes and the progression of many diseases. We design and fabricate unique bioengineering tools and biomaterials to unleash the potential of stem cells. For example, synthetic substrates strongly promote motor neuron differentiation of human pluripotent stem cells, which may be used to study and treat degenerative diseases like ALS.
Acoustic tweezing cytometry (ATC) is a novel technology using ultrasound and lipid microbubbles to apply mechanical forces to cells through intergin-cytoskeleton network.
We make lab-on-a-chip type of devices to control cell microenviroment, apply mechanical and chemical stimulation, model the morphological and functional feature of tissues in vivo.
Check out our newest review paper on engineered in vitro organogenesis here. This paper is featured as the front cover.Read more
Our newest work on in vitro neural plate model has been published in Nature Materials. See the paper and news articles [Michigan News] [UMass News]. See the News and Views by Mukul Tewary & Peter W. Zandstra [Nature Materials]Read more
4/15/2018 Nariman’s team (KINASE INC) won the 3rd place and $15,000 in the final round of the Innovation Challenge. Congratulations!!! [News]Read more