A Catalog of Early Lethal KOMP Phenotypes

(SCROLL DOWN THROUGH ALL GENE SPECIFIC DATA)

We have characterized a large number of mutant alleles generated by the Knock-out Mouse Consortium (KOMP2) that have lethal phenotypes occurring before to E9.5.  Thus far we have analyzed more than 100 distinct  knockout lines produced by the Knock Out Mouse Project. Here we provide data summarizing each early lethal mutant phenotype. More information about the international effort to understand the function of all protein coding genes available on the International Mouse Phenotyping Consortium website.  We find approximately half of homozygous knockout embryos can be recovered at E7.5 but arrest prior to gastrulation.  The other half cannot be found at E7.5 but are recovered during preimplantation stages with ~25% arresting/dying prior to blastocyst formation while the other ~25% form normal blastocysts but fail to implant. To our knowledge this is the first systematic study of early lethal knockouts conducted using similar mutation strategies on the same genetic background (C57Bl/6JN).  Summary data for each phenotype available below. Full data sets and information available by contacting Dr. Jesse Mager (jmager@umass.edu).

4933427D14Rik

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IMPC data for 4933427D14Rik

MGI data for 4933427D14Rik

OMIM data for 4933427D14Rik

ExAC data for 4933427D14Rik

Aasdhppt

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IMPC data for Aasdhppt

MGI data for Aasdhppt

OMIM data for Aasdhppt

ExAC data for Aasdhppt

Actr8

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IMPC data for Actr8

MGI data for Actr8

OMIM data for Actr8

ExAC data for Actr8

Alg14

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IMPC data for Alg14

MGI data for Alg14

OMIM data for Alg14

ExAC data for Alg14

Ap2s1

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IMPC data for Ap2s1

MGI data for Ap2s1

OMIM data for Ap2s1

ExAC data for Ap2s1

Atp2b1

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IMPC data for Atp2b1

MGI data for Atp2b1

OMIM data for Atp2b1

ExAC data for Atp2b1

B4gat1

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IMPC data for B4gat1

MGI data for B4gat1

OMIM data for B4gat1

ExAC data for B4gat1

BC052040

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IMPC data for BC052040

MGI data for BC052040

OMIM data for BC052040

ExAC data for BC052040

Bcs1l

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IMPC data for Bcs1l

MGI data for Bcs1l

OMIM data for Bcs1l

ExAc data for Bcs1l

Borcs6

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IMPC data for Borcs6

MGI data for Borcs6

OMIM data for Borcs6

Exac data for Borcs6

Casc3

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IMPC data for Casc3

MGI data for Casc3

OMIM data for Casc3

ExAC data for Casc3

Ccdc59

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IMPC data for Ccdc59

MGI data for Ccdc59

OMIM data for Ccdc59

ExAC data for Ccdc59

Cenpo

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IMPC data for Cenpo

MGI data for Cenpo

OMIM data for Cenpo

ExAC data for Cenpo

Clpx

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IMPC data for Clpx

MGI data for Clpx

OMIM data for Clpx

ExAC data for Clpx

Dbr1

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IMPC data for Dbr1

MGI data for Dbr1

OMIM data for Dbr1

ExAC data for Dbr1

Dctn6

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IMPC data for Dctn6

MGI data for Dctn6

OMIM data for Dctn6

ExAC data for Dctn6

Ddx59

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IMPC data for Ddx59

MGI data for Ddx59

OMIM data for Ddx59

ExAC data for Ddx59

Dnaaf2

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IMPC data for Dnaaf2

MGI data for Dnaaf2

OMIM data for Dnaaf2

ExAC data for Dnaaf2

Dolk

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IMPC data for Dolk

MGI data for Dolk

OMIM data for Dolk

ExAC data for Dolk

Eipr1

In process

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IMPC data for Eipr1

MGI data for Eipr1

OMIM data for Eipr1

ExAC data for Eipr1

Elof1

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Click HERE for our recent paper “The elongation factor Elof1 is required for mammalian gastrulation.

IMPC data for Elof1

MGI data for Elof1

OMIM data for Elof1

ExAC data for Elof1

Exoc2

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IMPC data for Exoc2

MGI data for Exoc2

OMIM data for Exoc2

ExAC data for Exoc2

Fastkd5

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IMPC data for Fastkd5

MGI data for Fastkd5

OMIM data for Fastkd5

ExAC data for Fastkd5

Glrx3

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IMPC data for Glrx3

MGI data for Glrx3

OMIM data for Glrx3

ExAC data for Glrx3

Hlcs

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IMPC data for Hlcs

MGI data for Hlcs

OMIM data for Hlcs

ExAC data for Hlcs

Ipo11

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IMPC data for Ipo11

MGI data for Ipo11

OMIM data for Ipo11

ExAC data for Ipo11

Isca1

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IMPC data for Isca1

MGI data for Isca1

OMIM data for Isca1

ExAC data for Isca1

Mars2

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IMPC data for Mars2

MGI data for Mars2

OMIM data for Mars2

ExAC data for Mars2

Mcrs1

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IMPC data for Mcrs1

MGI data for Mcrs1

OMIM data for Mcrs1

ExAC data for Mcrs1

Med20

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Cui et al “Med20 is essential for early embryogenesis and regulates Nanog expression.” Reproduction 2018

IMPC data for Med20

MGI data for Med20

OMIM data for Med20

ExAC data for Med20

Mepce

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IMPC data for Mepce

MGI data for Mepce

OMIM data for Mepce

ExAC data for Mepce

Mrm3

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IMPC data for Mrm3

MGI data for Mrm3

OMIM data for Mrm3

ExAC data for Mrm3

Mrpl22

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IMPC data for Mrpl22

MGI data for Mrpl22

OMIM data for Mrpl22

ExAC data for Mrpl22

Mrpl3

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IMPC data for Mrpl3

MGI data for Mrpl3

OMIM data for Mrpl3

ExAC data for Mrpl3

Mrpl44

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IMPC data for Mrpl44

MGI data for Mrpl44

OMIM data for Mrpl44

ExAC data for Mrpl44

Mrps18c

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IMPC data for Mrps18c

MGI data for Mrps18c

OMIM data for Mrps18c

ExAC data for Mrps18c

Mrps22

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IMPC data for Mrps22

MGI data for Mrps22

OMIM data for Mrps22

ExAC data for Mrps22

Mrps25

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IMPC data for Mrps25

MGI data for Mrps25

OMIM data for Mrps25

ExAC data for Mrps25

Mtpap

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IMPC data for Mtpap

MGI data for Mtpap

OMIM data for Mtpap

ExAC data for Mtpap

Nars2

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IMPC data for Nars2

MGI data for Nars2

OMIM data for Nars2

ExAC data for Nars2

Ndufa9

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IMPC data for Ndufa9

MGI data for Ndufa9

OMIM data for Ndufa9

ExAC data for Ndufa9

Ndufs8

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IMPC data for Ndufs8

MGI data for Ndufs8

OMIM data for Ndufs8

ExAC data for Ndufs8

Nup155

In process

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IMPC data for Nup155

MGI data for Nup155

OMIM data for Nup155

ExAC data for Nup155

Orc6

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IMPC data for Orc6

MGI data for Orc6

OMIM data for Orc6

ExAC data for Orc6

Pmpcb

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IMPC data for Pmpcb

MGI data for Pmpcb

OMIM data for Pmpcb

ExAC data for Pmpcb

Pold2

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IMPC data for Pold2

MGI data for Pold2

OMIM data for Pold2

ExAC data for Pold2

Polr1a

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IMPC data for Polr1a

MGI data for Polr1a

OMIM data for Polr1a

ExAC data for Polr1a

Polr1d

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IMPC data for Polr1d

MGI data for Polr1d

OMIM data for Polr1d

ExAC data for Polr1d

Ppp1r35

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IMPC data for Ppp1r35

MGI data for Ppp1r35

OMIM data for Ppp1r35

ExAC data for Ppp1r35

Prim1

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IMPC data for Prim1

MGI data for Prim1

OMIM data for Prim1

ExAC data for Prim1

Prpf40a

In Process

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IMPC data for Prpf40a

MGI data for Prpf40a

OMIM data for Prpf40a

ExAC data for Prpf40a

Prpf4b

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IMPC data for Prpf4b

MGI data for Prpf4b

OMIM data for Prpf4b

ExAC data for Prpf4b

Rab11a

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IMPC data for Rab11a

MGI data for Rab11a

OMIM data for Rab11a

ExAC data for Rab11a

Ranbp2

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IMPC data for Ranbp2

MGI data for Ranbp2

OMIM data for Ranbp2

ExAC data for Ranbp2

Rbbp4

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IMPC data for Rbbp4

MGI data for Rbbp4

OMIM data for Rbbp4

ExAC data for Rbbp4

Riok1

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IMPC data for Riok1

MGI data for Riok1

OMIM data for Riok1

ExAC data for Riok1

Rpain

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IMPC data for Rpain

MGI data for Rpain

OMIM data for Rpain

ExAC data for Rpain

Sars

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IMPC data for Sars

MGI data for Sars

OMIM data for Sars

ExAC data for Sars

Sdhaf2

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IMPC data for Sdhaf2

MGI data for Sdhaf2

OMIM data for Sdhaf2

ExAC data for Sdhaf2

Ska2

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IMPC data for Ska2

MGI data for Ska2

OMIM data for Ska2

ExAC data for Ska2

Snapc2

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IMPC data for Snapc2

MGI data for Snapc2

OMIM data for Snapc2

ExAC data for Snapc2

Sptssa

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IMPC data for Sptssa

MGI data for Sptssa

OMIM data for Sptssa

ExAC data for Sptssa

 Strn3

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IMPC data for Strn3

MGI data for Strn3

OMIM data for Strn3

ExAC data for Strn3 

Timm22

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IMPC data for Timm22

MGI data for Timm22

OMIM data for Timm22

ExAC data for Timm22

Tmx2

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IMPC data for Tmx2

MGI data for Tmx2

OMIM data for Tmx2

ExAC data for Tmx2 

Tomm20

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IMPC data for Tomm20

MGI data for Tomm20

OMIM data for Tomm20

ExAC data for Tomm20

Tpk1

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IMPC data for Tpk1

MGI data for Tpk1

OMIM data for Tpk1

ExAC data for Tpk1

Trit1

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IMPC data for Trit1

MGI data for Trit1

OMIM data for Trit1

ExAC data for Trit1

Tubgcp4

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IMPC data for Tubgcp4

MGI data for Tubgcp4

OMIM data for Tubgcp4

ExAC data for Tubgcp4

Ube2m

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IMPC data for Ube2m

MGI data for Ube2m

OMIM data for Ube2m

ExAC data for Ube2m

Utp4

In Process

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IMPC data for Utp4

MGI data for Utp4

OMIM data for Utp4

ExAC data for Utp4

Washc4

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IMPC data for Washc4

MGI data for Washc4

OMIM data for Washc4

ExAC data for Washc4

Ylpm1

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IMPC data for Ylpm1

MGI data for Ylpm1

OMIM data for Ylpm1

ExAC data for Ylpm1

Zc3h4

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IMPC data for Zc3h4

MGI data for Zc3h4

OMIM data for Zc3h4

ExAC data for Zc3h4

Zfp407

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IMPC data for Zfp407

MGI data for Zfp407

OMIM data for Zfp407

ExAC data for Zfp407

 Zwint

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IMPC data for Zwint

MGI data for Zwint

OMIM data for Zwint

ExAC data for Zwint

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