A Catalog of Early Lethal KOMP Phenotypes

(SCROLL DOWN THROUGH ALL GENE SPECIFIC DATA)

We have characterized a large number of mutant alleles generated by the Knock-out Mouse Consortium (KOMP2) that have lethal phenotypes occurring before to E9.5. As shown below we have established an efficient strategy to rapidly assess mutants that cannot be recovered at embryonic day 9.5. Thus far we have analyzed more than 100 distinct  knockout lines produced by the Knock Out Mouse Project. More information on the international effort to understand the function of all protein coding genes available on the International Mouse Phenotyping Consortium website.  Here we provide data summarizing each early lethal mutant phenotype. Thus far we have found approximately half of homozygous knockout embryos can be recovered at E7.5 but arrest prior to gastrulation.  The other half cannot be found at E7.5 but are recovered during preimplantation stages with ~25% arresting/dying prior to blastocyst formation while the other ~25% form normal blastocysts but fail to implant.

This primary screen provides baseline analysis of novel knockout phenotypes. To our knowledge this is the first systematic study of early lethal knockouts conducted using similar mutation strategies on the same genetic background (C57Bl/6JN).  Summary data for each phenotype available below. Full data sets and information available by contacting Dr. Jesse Mager (jmager@umass.edu).

4933427D14Rik

Click HERE for high resolution 4933427D14Rik data slide

IMPC data for 4933427D14Rik

MGI data for 4933427D14Rik

OMIM data for 4933427D14Rik

ExAC data for 4933427D14Rik

Aasdhppt

Aasdhppt gene knockout mutation embryoClick HERE for high resolution Aasdhppt data slide

IMPC data for Aasdhppt

MGI data for Aasdhppt

OMIM data for Aasdhppt

ExAC data for Aasdhppt

Actr8

Actr8 gene knockout embryoClick HERE for high resolution Actr8 data slide

IMPC data for Actr8

MGI data for Actr8

OMIM data for Actr8

ExAC data for Actr8

Alg14

Alg14 gene knockout embryClick HERE for high resolution Alg14 data slide

IMPC data for Alg14

MGI data for Alg14

OMIM data for Alg14

ExAC data for Alg14

Ap2s1

Ap2s1 gene knockout embryo lethal phenotypeClick HERE for high resolution Ap2s1 data slide

IMPC data for Ap2s1

MGI data for Ap2s1

OMIM data for Ap2s1

ExAC data for Ap2s1

Atp2b1

Atp2b1 gene knockout embryoClick HERE for high resolution Atp2b1 data slide

IMPC data for Atp2b1

MGI data for Atp2b1

OMIM data for Atp2b1

ExAC data for Atp2b1

B4gat1

B4gat1 gene knockout embryoClick HERE for high resolution B4gat1 data slide

IMPC data for B4gat1

MGI data for B4gat1

OMIM data for B4gat1

ExAC data for B4gat1

BC052040

BC052040 gene knockout embryoClick HERE for high resolution BC0502040 data slide

IMPC data for BC052040

MGI data for BC052040

OMIM data for BC052040

ExAC data for BC052040

Bcs1l

Bcs1l gene knockout embryo Click HERE for high resolution Bcs1l data slide

IMPC data for Bcs1l

MGI data for Bcs1l

OMIM data for Bcs1l

ExAc data for Bcs1l

Borcs6

Borcs6 gene knockout embryoClick HERE for high resolution Borcs6 data slide

IMPC data for Borcs6

MGI data for Borcs6

OMIM data for Borcs6

Exac data for Borcs6

Casc3

Casc3 gene knockout embryoClick HERE for high resolution Casc3 data slide

IMPC data for Casc3

MGI data for Casc3

OMIM data for Casc3

ExAC data for Casc3

Ccdc59

ccdc59 gene knockout embryoClick HERE  for high resolution Ccdc59 data slide

IMPC data for Ccdc59

MGI data for Ccdc59

OMIM data for Ccdc59

ExAC data for Ccdc59

Cenpo

Cenpo gene knockout embryoClick Here for high resolution Cenpo data slide

IMPC data for Cenpo

MGI data for Cenpo

OMIM data for Cenpo

ExAC data for Cenpo

Clpx

Clpx gene knockout embryoClick HERE for high resolution Clpx data slide

IMPC data for Clpx

MGI data for Clpx

OMIM data for Clpx

ExAC data for Clpx

Dbr1

Dbr1 gene knockout embryoClick HERE for high resolution Dbr1 data slide

IMPC data for Dbr1

MGI data for Dbr1

OMIM data for Dbr1

ExAC data for Dbr1

Dctn6

Dctn6 gene knockout embryoClick HERE for high resolution Dctn6 data slide

IMPC data for Dctn6

MGI data for Dctn6

OMIM data for Dctn6

ExAC data for Dctn6

Ddx59

Ddx59 gene knockout embryoClick HERE for high resolution Ddx59 data slide

IMPC data for Ddx59

MGI data for Ddx59

OMIM data for Ddx59

ExAC data for Ddx59

Dnaaf2

Dnaaf2 gene knockout embryoClick HERE for high resolution Dnaaf2 data slide

IMPC data for Dnaaf2

MGI data for Dnaaf2

OMIM data for Dnaaf2

ExAC data for Dnaaf2

Dolk1

Dolk1 gene mutation knockout phenotype embryo lethalClick HERE for Dolk high resolution data slide

IMPC data for Dolk

MGI data for Dolk

OMIM data for Dolk

ExAC data for Dolk

Eipr1

In process

Click HERE for Eipr1 high resolution data slide

IMPC data for Eipr1

MGI data for Eipr1

OMIM data for Eipr1

ExAC data for Eipr1

Elof1

Elof1 gene knockout embryoClick HERE for high resolution Elof1 data slide

Click HERE for our recent paper “The elongation factor Elof1 is required for mammalian gastrulation.

IMPC data for Elof1

MGI data for Elof1

OMIM data for Elof1

ExAC data for Elof1

Exoc2

Exoc2 gene knockout embryoClick HERE for high resolution Exoc2 data slide

IMPC data for Exoc2

MGI data for Exoc2

OMIM data for Exoc2

ExAC data for Exoc2

Fastkd5

Fastkd5 gene knockout embryoClick HERE for high resolution Fastkd5 data slide

IMPC data for Fastkd5

MGI data for Fastkd5

OMIM data for Fastkd5

ExAC data for Fastkd5

Glrx3

Glrx3 gene knockout embryoClick HERE for high resolution Glrx3 data slide

IMPC data for Glrx3

MGI data for Glrx3

OMIM data for Glrx3

ExAC data for Glrx3

Hlcs

Hlcs gene knockout phenotype embryo lethalClick HERE for Hlcs high resolution data slide

IMPC data for Hlcs

MGI data for Hlcs

OMIM data for Hlcs

ExAC data for Hlcs

Ipo1

Ipo11 gene knockout embryoClick HERE for high resolution Ipo1 data slide

IMPC data for Ipo11

MGI data for Ipo11

OMIM data for Ipo11

ExAC data for Ipo11

Isca1

Isac1 gene knockout embryoClick HERE for high resolution Isca1 data slide

IMPC data for Isca1

MGI data for Isca1

OMIM data for Isca1

ExAC data for Isca1

Mars2

Mars2 gene knockout embryoClick HERE for high resolution Mars2 data slide

IMPC data for Mars2

MGI data for Mars2

OMIM data for Mars2

ExAC data for Mars2

Mcrs1

Mcrs1 gene knockout embryoClick HERE for high resolution Mcrs1 data slide

IMPC data for Mcrs1

MGI data for Mcrs1

OMIM data for Mcrs1

ExAC data for Mcrs1

Med20

Med20 gene knockout embryoClick HERE for high resolution Med20 data slide

Cui et al “Med20 is essential for early embryogenesis and regulates Nanog expression.” Reproduction 2018

IMPC data for Med20

MGI data for Med20

OMIM data for Med20

ExAC data for Med20

Mepce

Mepce gene knockout embryoClick HERE for high resolution Mepce data slide

IMPC data for Mepce

MGI data for Mepce

OMIM data for Mepce

ExAC data for Mepce

 

Mrpl22

Mrpl22 gene knockout embryoClick HERE for high resolution Mrpl22 data slide

IMPC data for Mrpl22

MGI data for Mrpl22

OMIM data for Mrpl22

ExAC data for Mrpl22

Mrpl3

Mrpl3 gene knockout embryoClick HERE for high resolution Mrpl3 data slide

IMPC data for Mrpl3

MGI data for Mrpl3

OMIM data for Mrpl3

ExAC data for Mrpl3

Mrpl44

Mrpl44 gene knockout embryoClick HERE for high resolution Mrpl44 data slide

IMPC data for Mrpl44

MGI data for Mrpl44

OMIM data for Mrpl44

ExAC data for Mrpl44

Mrps18c

Mrps18c gene knockout embryoClick HERE for high resolution Mrps18c data slide

IMPC data for Mrps18c

MGI data for Mrps18c

OMIM data for Mrps18c

ExAC data for Mrps18c

Mrps22

Mrps22 gene knockout embryoClick HERE for high resolution Mrps22 data slide

IMPC data for Mrps22

MGI data for Mrps22

OMIM data for Mrps22

ExAC data for Mrps22

Mrps25

Mrps25 gene mutation knockout embryo lethalClick HERE for high resolution Mrps25 data slide

IMPC data for Mrps25

MGI data for Mrps25

OMIM data for Mrps25

ExAC data for Mrps25

Mtpap

Mtpap gene knockout embryoClick HERE for high resolution Mtpap data slide

IMPC data for Mtpap

MGI data for Mtpap

OMIM data for Mtpap

ExAC data for Mtpap

Nars2

Nars2 gene knockout embryoClick HERE for high resolution Nars2 data slide

IMPC data for Nars2

MGI data for Nars2

OMIM data for Nars2

ExAC data for Nars2

Ndufa9

Ndufa9 gene knockout embryoClick HERE for high resolution Ndufa9 data slide

IMPC data for Ndufa9

MGI data for Ndufa9

OMIM data for Ndufa9

ExAC data for Ndufa9

Ndufs8

ndufs8 gene mutation knockout phenotype embryo lethalClick HERE for high resolution Ndufs8 data slide

IMPC data for Ndufs8

MGI data for Ndufs8

OMIM data for Ndufs8

ExAC data for Ndufs8

Nup155

In process

Click HERE for high resolution Nup155 data slide

IMPC data for Nup155

MGI data for Nup155

OMIM data for Nup155

ExAC data for Nup155

Orc6

Orc6 gene knockout embryoClick HERE for high resolution Orc6 data slide

IMPC data for Orc6

MGI data for Orc6

OMIM data for Orc6

ExAC data for Orc6

Pmpcb

Pmpcb gene knockout embryoClick HERE for high resolution Pmpcb data slide

IMPC data for Pmpcb

MGI data for Pmpcb

OMIM data for Pmpcb

ExAC data for Pmpcb

Pold2

pold2 gene knockout phenotype embryo lethalClick HERE for high resolution Pold2 data slide

IMPC data for Pold2

MGI data for Pold2

OMIM data for Pold2

ExAC data for Pold2

Polr1a

Polr1a gene knockout embryoClick HERE for high resolution Polr1a data slide

IMPC data for Polr1a

MGI data for Polr1a

OMIM data for Polr1a

ExAC data for Polr1a

Polr1d

Polr1d gene knockout embryo

Click HERE for high resolution Polr1d data slide

IMPC data for Polr1d

MGI data for Polr1d

OMIM data for Polr1d

ExAC data for Polr1d

Ppp1r35

ppp1r35 gene knockout embryoClick HERE for Ppp1r35 high resolution data slide

IMPC data for Ppp1r35

MGI data for Ppp1r35

OMIM data for Ppp1r35

ExAC data for Ppp1r35

Prim1

Prim1 gene knockout mutation embryo lethal phenotype

Click HERE for high resolution Prim1 data slide

IMPC data for Prim1

MGI data for Prim1

OMIM data for Prim1

ExAC data for Prim1

Prpf40a

In Process

Click HERE for high resolution Prpf40a data slide

IMPC data for Prpf40a

MGI data for Prpf40a

OMIM data for Prpf40a

ExAC data for Prpf40a

Prpf4b

Prpf4b gene knockout embryoClick HERE for high resolution Prpf4b data slide

IMPC data for Prpf4b

MGI data for Prpf4b

OMIM data for Prpf4b

ExAC data for Prpf4b

Rab11a

Rab11a gene knockout embryoClick HERE for Rab11a high resolution data slide

IMPC data for Rab11a

MGI data for Rab11a

OMIM data for Rab11a

ExAC data for Rab11a

Ranbp2

Click HERE for high resolution Ranbp2 data slide

IMPC data for Ranbp2

MGI data for Ranbp2

OMIM data for Ranbp2

ExAC data for Ranbp2

Rbbp4

Rbbp4 gene knockout embryo phenotypeClick HERE for high resolution Rbbp4 data slide

IMPC data for Rbbp4

MGI data for Rbbp4

OMIM data for Rbbp4

ExAC data for Rbbp4

Riok1

Riok1 gene mutation knockout phenotype embryo lethalClick HERE for high resolution Riok1 data slide

IMPC data for Riok1

MGI data for Riok1

OMIM data for Riok1

ExAC data for Riok1

Rnmtl1

Rnmtl1 gene knockout embryoClick HERE for high resolution Rnmtl1 data slide

IMPC data for Rnmtl1

MGI data for Rnmtl1

OMIM data for Rnmtl1

ExAC data for Rnmtl1

Rpain

Rpain gene knockout embryoClick HERE for high resolution Rpain data slide

IMPC data for Rpain

MGI data for Rpain

OMIM data for Rpain

ExAC data for Rpain

Sars

Sars gene knockout embryoClick HERE for high resolution Sars data slide

IMPC data for Sars

MGI data for Sars

OMIM data for Sars

ExAC data for Sars

Sdhaf2Click HERE for high resolution Sdhaf2 data slide

IMPC data for Sdhaf2

MGI data for Sdhaf2

OMIM data for Sdhaf2

ExAC data for Sdhaf2

Ska2

Ska2 gene knockout embryoClick HERE for high resolution Ska2 data slide

IMPC data for Ska2

MGI data for Ska2

OMIM data for Ska2

ExAC data for Ska2

Snapc2

Snapc2 gene knockout embryoClick HERE for high resolution Snapc2 data slide

IMPC data for Snapc2

MGI data for Snapc2

OMIM data for Snapc2

ExAC data for Snapc2

Sptssa

Sptssa gene knockout embryoClick HERE for high resolution Sptssa data slide

IMPC data for Sptssa

MGI data for Sptssa

OMIM data for Sptssa

ExAC data for Sptssa

 Strn3

Strn3 gene knockout embryoClick here for high resolution Strn3 data slide

IMPC data for Strn3

MGI data for Strn3

OMIM data for Strn3

ExAC data for Strn3 

Timm22

Timm22 gene knockout embryoClick HERE for high resolution Timm22 data slide

IMPC data for Timm22

MGI data for Timm22

OMIM data for Timm22

ExAC data for Timm22

Tmx2

Tmx2 gene knockout embryoClick HERE for high resolution Tmx2 data slide

IMPC data for Tmx2

MGI data for Tmx2

OMIM data for Tmx2

ExAC data for Tmx2 

Tomm20

Click HERE for high resolution Tomm20 data slide

IMPC data for Tomm20

MGI data for Tomm20

OMIM data for Tomm20

ExAC data for Tomm20

Tpk1

Tpk1 gene knockout phenotype embryo lethalClick HERE for high resolution Tpk1 data slide

IMPC data for Tpk1

MGI data for Tpk1

OMIM data for Tpk1

ExAC data for Tpk1

Trit1

Trit1 gene knockout embryoClick HERE for high resolution Trit1 data slide

IMPC data for Trit1

MGI data for Trit1

OMIM data for Trit1

ExAC data for Trit1

Tubgcp4

Tubgcp4 gene knockout embryoClick HERE for high resolution Tubgcp4 data slide

IMPC data for Tubgcp4

MGI data for Tubgcp4

OMIM data for Tubgcp4

ExAC data for Tubgcp4

Ube2m

Ube2m gene knockout embryoClick HERE for high resolution Ube2m data slide

IMPC data for Ube2m

MGI data for Ube2m

OMIM data for Ube2m

ExAC data for Ube2m

Utp4

In Process

Click HERE for high resolution Utp4 data slide

IMPC data for Utp4

MGI data for Utp4

OMIM data for Utp4

ExAC data for Utp4

Washc4

Washc4 gene knockout phenotype embryo lethalClick HERE for high resolution Wasch4 data slide

IMPC data for Washc4

MGI data for Washc4

OMIM data for Washc4

ExAC data for Washc4

Ylpm1

ylpm gene knockout phenotype embryo lethalClick HERE for high resolution Ylpm1 data slide

IMPC data for Ylpm1

MGI data for Ylpm1

OMIM data for Ylpm1

ExAC data for Ylpm1

Zc3h4

Zc3h4 gene knockout embryoClick HERE for high resolution Zc3h4 data slide

IMPC data for Zc3h4

MGI data for Zc3h4

OMIM data for Zc3h4

ExAC data for Zc3h4

Zfp407

Zfp407 gene knockout embryoClick HERE for high resolution Zfp407 data slide

IMPC data for Zfp407

MGI data for Zfp407

OMIM data for Zfp407

ExAC data for Zfp407

 Zwint

Zwint gene knockout embryoClick HERE for high resolution Zwint data slide

IMPC data for Zwint

MGI data for Zwint

OMIM data for Zwint

ExAC data for Zwint

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